In vivo scientific tests demonstrate anatomically selective neurochemical results of modafinil on monoaminergic techniques (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, whilst modafinil boosts TMN fos expression (Scammell et al 2000) and HAergic tone it is unable to exert this effect when administered straight in to the TMN (Ishi
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